Study on chloramphenicol resistance pattern in Central India, Indore

Authors

  • K Jain Department of Microbiology,Index Medical College Hospital & Research Centre, Indore, Madhya Pradesh, India
  • S Tripathi Department of Pharmacology, Index Medical College Hospital & Research Centre, Indore, Madhya Pradesh, India

Keywords:

Chloramphenicol, drug resistance, gram positive, gram negative organism

Abstract

Background- Chloramphenicol (CK) is drug of choice in many life threatening and serious bacterial infections. Due to development of resistance and toxicity associated with this drug, it is not in common use now days. This study was done to find out prevalence of CK resistance pattern.

Material Methods- 100 consecutive pus samples from surgical site infections from various specialties of index medical college hospital and research center were studied in microbiology department during period of 1year. 

Results- Gram positive as well as Gram negative organisms had shown sensitivity to Chloramphenicol. Also organisms were resistant to commonly used higher antibiotics.

Conclusion- CK can be used for common serious IPD patients not having contraindication to this drug. Study also reinforces proper and rational use of antibiotics.

References

Shukla P, Bansode FW, Singh RK. Chloramphenicol toxicity: A review. J Med Med Sci 2011:2;1313-6.

Rich ML, Ritterhoff RJ, Hoffmann RJ. A fatal case of aplastic anemia following chloramphenicol chloromycetin therapy. Ann Intern Med 1950;33:1459-67.

Ambekar CS, Cheung B, Lee J, Chan LC, Liang R, Kumana CR. Metabolism of chloramphenicol succinate in human bone marrow. Eur J Clin Pharmacol 2000;56:405-9.

Yunis AA. Chloramphenicol toxicity: 25 years of research. Am J Med 1989;87:44N-8N.

Turton AA, Andrews CM, Harvard AC, Williams TC. Studies on haematotoxicity of chloramphenicol succinate in Dunkin Hartley guinea pig. Int J Exp Pathol 2002;5:225-38.

Li CH, Cheng YW, Liao PL, Yang YT, Kang JJ. Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion. Toxicol Sci 2010;116:140-50.

Hutchison HE, Pinkerton PH. Marrow depression due to chloramphenicol. Scott Med J 1962;7:96-7.

Holt R. The bacterial degradation of chloramphenicol. Lancet 1967;1:1259-60.

Gleckman RA. Warning-chloramphenicol may be good for your health. Arch Intern Med 1975;135:1125-6.

Rosenthal RL, Blackman A. Bone-marrow hypoplasia following use of chloramphenicol eye drops. JAMA 1965;191:136-7.

Carpenter G. Letter: Chloramphenicol eye-drops and marrow aplasia. Lancet 1975;2:326-7.

Abrams SM, Degnan TJ, Vinciguerra V. Marrow aplasia following topical application of chloramphenicol eye ointment. Arch Intern Med 1980;140:576-7.

Reimann HA, D’Ambola J. The use and cost of antimicrobics in hospitals. Arch Environ Health 1966;13:631-6.

Howard RJ. Surgical infections. In: Schwartz Principles of Surgery. Vol. I. 7th ed. New York: McGraw Hill Inc.; 1999. p. 123-52.

Taye M. Wound infection in Tikur Anbessa hospital, surgical department. Ethiop Med J 2005;43:167-74.

Tesfahunegn Z, Asrat D, Woldeamanuel Y, Estifanos K. Bacteriology of surgical site and catheter related urinary tract infections among patients admitted in Mekelle Hospital, Mekelle, Tigray, Ethiopia. Ethiop Med J 2009;47:117-27.

Biadglegne F, Abera B, Alem A, Anagaw B. Bacterial isolates from wound infection and their antimicrobial susceptibility pattern in Felege Hiwot referral hospital, North West Ethiopia. Ethiop J Health Sci 2009;19:173-7.

Isibor JO, Oseni A, Eyaufe A, Osagie R, Turay A. Incidence of aerobic bacteria and Candida albicans in post-operative wound infections. Afr J Microbial Res 2008;2:288-91.

Adegoke AA, Tom M, Okoh AI, Jacob S. Studies on multiple antibiotic resistant bacteria isolated from surgical site infection. Sci Res Essays 2010;5:3876-81.

Siddiqi F, Masood MB, Saba N, Samad A, Qayyum M, Qazilbash AA. Antibiogram sensitivity pattern of methicillin resistant Staphylococcus aureus isolates from pus samples. Pak J Biol Sci 2002;5:491-3.

Mohanty S, Kapil A, Dhawan B, Das BK. Bacteriological and antimicrobial susceptibility profi le of soft tissue infections from Northern India. Indian J Med Sci 2004;58:10-5.

Vidhani S, Mathur MD, Mehndiratta PL, Rizvi M. Methicillin resistant Staphylococcus aureus (MRSA): The associated risk factors. Indian J Pathol Microbiol 2003;46:676-9.

Mulu A, Moges F, Tessema B, Kassu A. Pattern and multiple drug resistance of bacterial pathogens isolated from wound infection at University of Gondar Teaching Hospital, Northwest Ethiopia. Ethiop Med J 2006;44:125-31.

Gebre-Sealsssie S. Antimicrobial resistance patterns of clinical bacterial isolates in southwestern Ethiopia. Ethiop Med J 2007;45:363-70.

Bercion R, Gaudeuille A, Mapouka PA, Behounde T, Guetahoun Y. Surgical site infection survey in the orthopaedic surgery department of the “Hôpital communautaire de Bangui,” Central African Republic. Bull Soc Pathol Exot 2007;100:197-200.

Amrita S, Sheetal R, Narendra N. Aerobic micro-organisms in post-operative wound infections and their antimicrobial susceptibility patterns. J Clin Diagn Res 2010;4:3392-6.

Soleto L, Pirard M, Boelaert M, Peredo R, Vargas R, Gianella A, et al. Incidence of surgical-site infections and the validity of the National Nosocomial Infections Surveillance System risk index in a general surgical ward in Santa Cruz, Bolivia. Infect Control Hosp Epidemiol 2003;24:26-30.

Thanni LO, Osinupebi OA, Deji-Agboola M. Prevalence of bacterial pathogens in infected wounds in a tertiary hospital, 1995-2001: Any change in trend. J Natl Med Assoc 2003;95:1189-95.

Sharan H, Misra AP, Mishra R. Determinants of surgical site infection in rural Kanpur, India. J Evol Med Dent Sci 2012;1:921-8.

Gupta N, Prakash SK, Malik VK, Mehndiratta PL, Mathur MD. Community acquired methicillin resistant Staphylococcsus aureus: a new threat for hospital outbreaks. Indian J Pathol Microbiol 1999;42:421-6.

Anupurba S, Sen MR, Nath G, Sharma BM, Gulati AK, Mohapatra TM. Prevalence of methicillin resistant Staphylococcus aureus in a tertiary referral hospital in eastern Uttar Pradesh. Indian J Med Microbiol 2003;21:49-51.

Chaudhary U, Anupama. Prevalence of methicillin resistance in Staphylococcus aureus. Indian J Med Microbial 1999;17:154-5.

Anvikar AR, Deshmukh AB, Karyakarte RP, Damle AS, Patwardhan NS, Malik AK, et al. A one year prospective study of 3280 surgical wounds. Indian J Med Microbiol 1999;17:129-32.

Pulimood TB, Lalitha MK, Jesudason MV, Pandian R, Selwyn J, John TJ. The spectrum of antimicrobial resistance among methicillin resistant Staphylococcus aureus (MRSA) in a tertiary care centre in India. Indian J Med Res 1996;103:212-5.

Udaya Shankar C, Harish BN, Umesh Kumar PM, Navaneeth BV. Prevalence of methicillin resistant Staphylococcus aureus in JIPMER hospital a preliminary report. Indian J Med Microbiol 1997;15:137-8.

Downloads

Published

2015-03-31

How to Cite

Jain , K., & Tripathi , S. (2015). Study on chloramphenicol resistance pattern in Central India, Indore. International Journal of Medical Science Research and Practice, 2(1), 27–31. Retrieved from https://ijmsrp.isroset.org/index.php/j/article/view/31

Similar Articles

1 2 > >> 

You may also start an advanced similarity search for this article.