Unravelling the Patterns of Antinuclear Antibodies (ANA) Indirect Immunofluorescence Assay (IFA): Insights and Implications
Keywords:
ANA IFA, SLE, SSc, MCTD, RA, Sclerosis, CREST syndromeAbstract
The Antinuclear Antibodies (ANA) Indirect Immunofluorescence Assay (IFA) has long been a cornerstone for diagnosis and management of autoimmune diseases. This review aims to elucidate the diverse patterns observed in ANA IFA, exploring their clinical significance, diagnostic utility, and evolving implications in autoimmune diagnostics. We delve into the intricacies of interpreting ANA IFA patterns, emphasizing their correlation with specific autoimmune diseases and highlighting recent advancements in pattern recognition technologies. Furthermore, we discuss challenges, limitations, and future directions in ANA IFA interpretation, paving the way for enhanced precision and efficacy in autoimmune disease diagnosis.
References
Anne E. Tebo, Robert L. Schmidt, Kamran Kadkhoda, Lisa K. Peterson, Edward K. L. Chan, Marvin J. Fritzler, Mark H. Wener. “The antinuclear antibody HEp-2 indirect immunofluorescence assay: a survey of laboratory performance, pattern recognition and interpretation.” Auto- immunity highlights Vol. 12, Issue 4, pp 1-10, 2021, oi: 10.1186/s13317-020-00146-w
Damoiseaux J, Andrade LEC, Carballo OG, Conrad K, Francescantonio PLC, Fritzler MJ, Garcia de la Torre I, Herold M, Klotz W, Cruvinel WM, Mimori T, von Muhlen C, Satoh M, Chan EK. Clinical relevance of HEp-2 indirect immunofluorescent patterns: the International Consensus on ANA patterns (ICAP) perspective. Ann Rheum Dis. Vol 78,Issue 7, pp 879-889.2019 doi: 10.1136/annrheumdis-2018-214436.
Soto ME, Hernández-Becerril N, Perez-Chiney AC, Hernández-Rizo A, Telich-Tarriba JE, Juárez-Orozco LE, Melendez G, Bojalil R. Predictive value of antinuclear antibodies in autoimmune diseases classified by clinical criteria: Analytical study in a specialized health institute, one year follow-up. Results Immunol. Vol 9; Issue 5, pp 13-22 , 2013. doi: 10.1016/j.rinim.2013.10.003.
Zafer Mengeloglu, Tekin Tas, Esra Kocoglu, Gülali Aktas, and Seyda Karabörk. “Determination of Anti-nuclear Antibody Pattern Distribution and Clinical Relationship.” Pakistan journal of medical sciences Vol. 30, Issue 2, pp 380-383, 2014 , doi:10.12669/pjms.302.4276
Prishni Gupta, Pratishtha Agrawal, Neha Rani Verma, Seema Shah, Suprava Patel, Rachita Nanda, and Eli Mohapatra. “Antinuclear Antibody Profiling in Patients of a Tertiary Care Centre in Central India.” Indian journal of clinical biochemistry : Vol. 36, Issue 3, 345-352 ,2021. doi:10.1007/s12291-020-00925-2
Minoru Satoh, Monica Vázquez-Del Mercado, and Edward K. L. Chan. “Clinical interpretation of antinuclear antibody tests in systemic rheumatic diseases.” Modern rheumatology , Vol. 19, issue 3, pp 219-228, 2009. doi:10.1007/s10165-009-0155-3
Hyun Jin Cha, Jimin Hwang , Lucy Eunju Lee, Younhee Park, Jason Jungsik Song . “The significance of cytoplasmic antinuclear antibody patterns in autoimmune liver disease.” PloS one, Vol.16, Issue.1, pp.1-12 2021, doi:10.1371/journal.pone.0244950
Choi HW, Kwon YJ, Park JH, Lee SY, Chun S, Won EJ, Lee JH, Choi HJ, Kim SH, Shin MG, Shin JH, Kee SJ. Evaluation of a Fully Automated Antinuclear Antibody Indirect Immunofluorescence Assay in Routine Use. Front Immunol. 2020 Dec 4; Vol.11, Issue.1, pp.1-11, 2020 doi: 10.3389/fimmu.2020.607541.
Irure-Ventura, Juan, and Marcos López-Hoyos. “The Past, Present, and Future in Antinuclear Antibodies (ANA).” Diagnostics (Basel, Switzerland) , Vol.12, Issue.647. pp1-12, 2022. Doi:10.3390/diagnostics12030647
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors contributing to this journal agree to publish their articles under the Creative Commons Attribution 4.0 International License, allowing third parties to share their work (copy, distribute, transmit) and to adapt it, under the condition that the authors are given credit and that in the event of reuse or distribution, the terms of this license are made clear.
