Bisalbuminemia: Insights into its Clinical Manifestations, Diagnostic Complexities, and Relevance in Modern Medicine

Abstract

Bisalbuminemia, also known as alloalbuminemia, is a rare hematologic disorder characterized by the presence of two distinct serum albumin fractions in the blood. This condition is typically benign and asymptomatic, but its discovery can be puzzling for clinicians due to its rarity and often incidental nature. The occurrence of bisalbuminemia can be hereditary or acquired, with the hereditary form being passed down in an autosomal dominant fashion, while the acquired form is linked to liver disease, kidney disease, or drug exposure. The condition is most commonly identified during routine serum protein electrophoresis (SPE) testing, when an unusual albumin pattern is observed. In this report, we present a case of a patient diagnosed with bisalbuminemia. We discuss the clinical presentation, diagnostic challenges, and management strategies, emphasizing the importance of considering rare hematologic conditions in patients presenting with unexplained hypoalbuminemia and abnormal serum protein electrophoresis results. This case underscores the need for awareness of such conditions among clinicians and laboratory personnel to avoid unnecessary testing and misdiagnoses.